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reported the kinetics of the two different GDH forms from the bovine brain (bGDH1 and bGDH2) ( GDH in brain development Since glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS), mitochondrial function and glutamate metabolism are closely related in the brain ( Target neurons are depolarized by glutamate produced by active synapses via certain receptors (Spreafico et al., 1994)

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In a genome-wide CRISPR-Cas9 screening conducted in the presence of the RSL3, ALOX15 was identified as an essential driver of ferroptosis through its role in the PUFAs